单抗助力【GLP-1】及【Exendin-4】新功能探索

来源：作者：人气：-发表时间：2016-08-10 12:10:00【大中小】

亚星官网yaxin111代理BioPorto GLP-1及Exendin-4相关单克隆抗体。科学家们从希拉毒蜥唾液中分离得到一种肽类物质Exendin-4，它与哺乳动物GLP-1有53%的同源，N端的同源性更是高达80%。该多肽与GLP-1有同样的促胰岛素分泌的作用，且稳定性远远高于GLP-1。

GLP-1及Exendin-4的作用

GLP-1是由末端空肠、回肠和结肠的Langerhans细胞分泌的一种多肽，主要生理功能包括具有葡萄糖依赖的胰岛素促泌作用。

由于GLP-1在人体内半衰期仅有2分钟左右，可被二肽激肽酶(DPP-Ⅳ)快速降解而失去活性，其生物学效应受到很大限制。Exendin-4具有与GLP-1相似的生理功能，但Exendin-4的半衰期达9.57小时，在临床应用时具有优势，GLP-1及其受体激动剂Exendin-4成为具有广阔应用前景。

GLP-1及Exendin-4的其它生理功能

GLP-1及Exendin-4可延迟胃的排空，引起胞胀感的产生并抑制食物的摄取；
GLP-1及Exendin-4对神经细胞有促增殖再生和抗凋亡的保护作用，可对抗多种因素引起的神经元氧化损伤，提示其将来可扩展到用于阿尔兹海默症和帕金森等神经退行性疾病的研究；
GLP-1R在心脏区域也有表达，提示其在心脏也可能发挥某些生理功能。

BioPorto GLP-1单克隆抗体

BioPorto致力于开发疾病研究相关的单克隆抗体、抗原及诊断试剂盒。胰高血糖素样肽-1(GLP-1) 存在多种剪切体，包括GLP-1 Extended form、GLP-1 Active form及GLP-1 Metabolite等：

货号	产品名称	规格	宿主	应用
ABS 033-04-02	Glucagon-like peptide-1 (GLP-1(7-37) and GLP-1(7-36)amide, N-terminal specific)	200µl	Mouse	ELISA, IHC
ABS 033-04-1	Glucagon-like peptide-1 (GLP-1(7-37) and GLP-1(7-36)amide, N-terminal specific)	1ml	Mouse	ELISA, IHC
ABS 033-10-02	Glucagon-like peptide-1 (GLP-1(7-37) and GLP-1(7-36)amide, N-terminal specific)	200µl	Mouse	ELISA, WB
ABS 033-10-1	Glucagon-like peptide-1 (GLP-1(7-37) and GLP-1(7-36)amide, N-terminal specific)	1ml	Mouse	ELISA, WB
ABS 033-10B-005	Glucagon-like peptide-1 (GLP-1(7-37) and GLP-1(7-36)amide, N-terminal specific)	50µl	Mouse	ELISA
ABS 044-49-02	Glucagon-like peptide-1 (GLP-1(9-37) and GLP-1(9-36)amide, N-terminal specific)	200µl	Mouse	ELISA, WB
ABS 044-49-1	Glucagon-like peptide-1 (GLP-1(9-37) and GLP-1(9-36)amide, N-terminal specific)	1ml	Mouse	ELISA, WB
ABS 044-53-02	Glucagon-like peptide-1 (GLP-1(9-37) and GLP-1(9-36)amide, N-terminal specific)	200µl	Mouse	ELISA, WB
ABS 044-53-1	Glucagon-like peptide-1 (GLP-1(9-37) and GLP-1(9-36)amide, N-terminal specific)	1ml	Mouse	ELISA, WB
ABS 046-03-02	Glucagon-like peptide-1 (GLP-1, Non-amidated (-Arg-Gly), C-terminal specific)	200µl	Mouse	ELISA, WB
ABS 046-03-1	Glucagon-like peptide-1 (GLP-1, Non-amidated (-Arg-Gly), C-terminal specific)	1ml	Mouse	ELISA, WB
ABS 046-03B-005	Glucagon-like peptide-1 (GLP-1, Non-amidated (-Arg-Gly), C-terminal specific)	50µl	Mouse	ELISA
HYB 011-05-02	Glucagon-like peptide-1 (GLP-1(1-36)amide, N-terminal-extension specific)	200µl	Mouse	ELISA, WB
HYB 011-05-1	Glucagon-like peptide-1 (GLP-1(1-36)amide, N-terminal-extension specific)	1ml	Mouse	ELISA, WB
HYB 147-06-02	Glucagon-like peptide-1 (GLP-1 (7-36)amide, C-terminal specific)	200µl	Mouse	ELISA, IHC
HYB 147-06-1	Glucagon-like peptide-1 (GLP-1 (7-36)amide, C-terminal specific)	1ml	Mouse	ELISA, IHC
HYB 147-06B-005	Glucagon-like peptide-1 (GLP-1 (7-36)amide, C-terminal specific)	50µl	Mouse	ELISA
HYB 147-08-02	Glucagon-like peptide-1 (GLP-1, Mid-molecule specific)	200µl	Mouse	ELISA, WB
HYB 147-08-1	Glucagon-like peptide-1 (GLP-1, Mid-molecule specific)	1ml	Mouse	ELISA, WB
HYB 147-08B-005	Glucagon-like peptide-1 (GLP-1, Mid-molecule specific)	50µl	Mouse	ELISA
HYB 147-12-02	Glucagon-like peptide-1 (GLP-1, Mid-molecule specific)	200µl	Mouse	ELISA, WB, IHC
HYB 147-12-1	Glucagon-like peptide-1 (GLP-1, Mid-molecule specific)	1ml	Mouse	ELISA, WB, IHC
HYB 147-12B-005	Glucagon-like peptide-1 (GLP-1, Mid-molecule specific)	50µl	Mouse	ELISA
HYB 147-13-02	Glucagon-like peptide-1 (GLP-1, Mid-molecule specific)	200µl	Mouse	ELISA, WB
HYB 147-13-1	Glucagon-like peptide-1 (GLP-1, Mid-molecule specific)	1ml	Mouse	ELISA, WB
HYB 006-02-02	Glucagon-like peptide-2 (human, GLP-2)	200µl	Mouse	ELISA
HYB 006-02-1	Glucagon-like peptide-2 (human, GLP-2)	1ml	Mouse	ELISA

BioPorto Exendin-4单克隆抗体

货号	产品名称	规格	宿主	应用
ABS 012-20-02	Exendin-4	200µl	Mouse	ELISA
ABS 012-20-1	Exendin-4	1ml	Mouse	ELISA
ABS 012-24-02	Exendin-4	200µl	Mouse	ELISA
ABS 012-24-1	Exendin-4	1ml	Mouse	ELISA
ABS 012-35-02	Exendin-4	200µl	Mouse	ELISA
ABS 012-35-1	Exendin-4	1ml	Mouse	ELISA
ABS 012-35B-005	Exendin-4	50µl	Mouse	ELISA